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Phosphorylative Inactivation of Aminoglycosidic Antibiotics by <i>Escherichia coli</i> Carrying R Factor
131
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0
References
1967
Year
Original AntibioticsBacteriologyEnzyme SolutionEscherichia ColiAntimicrobial ChemotherapyEnzymatic ModificationDrug ResistanceAntibacterial MechanismsAntimicrobial ResistanceBiochemistryVirulence FactorAntimicrobial CompoundMolecular MicrobiologyPhosphorylative InactivationAntimicrobial SusceptibilityAntibioticsAminoglycosidic AntibioticsMicrobiologyMedicine
Kanamycin and paromamine are inactivated by an enzyme solution prepared from Escherichia coli carrying R factor; and the 3-hydroxyl group of 6-amino-6-deoxy-D-glucose moiety of kanamycin or the 3-hydroxyl group of glucosamine moiety of paromamine is phosphorylated. These inactivated products and dihydrostreptomycin inactivated by the enzyme solution are converted to the original antibiotics by treatment with alkaline phosphatase.