Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channels.

Abstract

Retinal function is mildly impaired in AQP4-null mice, suggesting a role for AQP4 in Müller cell fluid balance. These results support the paradigm that AQP4 expression in supportive cells in the nervous system facilitates neural signal transduction in nearby electrically excitable cells.