JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB₁receptor agonist

Abstract

JWH018, a prominent component of several herbal preparations marketed for their psychoactivity, is a potent and effective CB(1) receptor agonist that activates multiple CB(1) receptor signalling pathways. Thus, it is likely that the subjective effects of 'Spice' are due to activation of cannabinoid CB(1) receptors by JWH018, added to this herbal preparation.