α- and β-Adrenergic Receptors as Mediators of Accumulation of Cyclic Adenosine 3',5'-Monophosphate in Specific Areas of Guinea Pig Brain

Abstract

With slices derived from two areas of guinea pig brain, cerebellum, and cerebrum plus brain stem, we have shown that specific, and different, receptors exist in these two brain areas for the control of cyclic adenosine 3',5'-monophosphate (cyclic AMP) levels.The cerebellum contains a single type of receptor,shown to be a classical /3-adrenergic receptor.The remainder of the brain was shown to have at least two types of receptors mediating increases in cyclic AMP.One, specific for catecholamines, was shown to be a classical cr-adrenergic receptor.The other, specific for histamine, could be blocked by a number of antihistaminic agents.This report is the first to show that both CY-and P-adrenergic stimulation can increase cyclic AMP levels.