Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?

Abstract

The IGF[3][1] system is composed of the two peptide ligands (IGF-I and IGF-II), six high-affinity IGF-binding proteins (IGFBP-1 to IGFBP-6), and two IGF receptors (IGF-IR and IGF-IIR), of which IGF-IR confers most of the biological actions of IGFs [(1][2] [, 2)][3] . The actions of IGFs may be