PubMed · 2001 · 170 citations · 164 references
MedicineCancer BiologyEndocrinologyCarcinogenesisGene RegulationTranscriptional RegulationGrowth Factor SignalingOncogenic Signaling PathwaysPromoter RegulationTranscription FactorsTumor PromotionTumor Suppressor GenesGrowth Factor-receptor InteractionsInsulin-like Growth Factor Receptor SignalingInsulin-like Growth Factor-1Insulin-like Growth FactorsPromoter-induced Cell ProliferationTumor Promoter Mechanisms
The IGF[3][1] system is composed of the two peptide ligands (IGF-I and IGF-II), six high-affinity IGF-binding proteins (IGFBP-1 to IGFBP-6), and two IGF receptors (IGF-IR and IGF-IIR), of which IGF-IR confers most of the biological actions of IGFs [(1][2] [, 2)][3] . The actions of IGFs may be
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Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Peter Carmeliet, Yuval Dor, Jean-Marc Herbert et al. · Nature · 1998 · 2.5K citations
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.
David M. Feldser, Faton Agani, Narayan V. Iyer et al. · PubMed · 1999 · 643 citations
Medicine, Biochemistry, Oncology +17