ADRENO-SYMPATHOGENIC HEART DISEASE (NEUROHORMONAL FACTORS IN PATHOGENESIS AND TREATMENT)

Abstract

Article1 May 1948ADRENO-SYMPATHOGENIC HEART DISEASE (NEUROHORMONAL FACTORS IN PATHOGENESIS AND TREATMENT)W. RAAB, M.D., F.A.C.P.W. RAAB, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-5-1010 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost of the non-congenital and non-infectious forms of heart disease are generally attributed to mechanical factors, such as the "burden," "load," "strain" of high blood pressure in "hypertensive" heart disease or to impairment of coronary blood flow in "arteriosclerotic" heart disease. In either one of these conditions a relative or absolute deficiency of the myocardial oxygen supply is believed to exist and to contribute essentially to functional and ultimately structural lesions of the heart.Little or no emphasis is being put on the fact that the typical clinical features of "hypertensive" heart disease are not infrequently found without hypertension and...Bibliography1. BLIX G: Ueber Adrenalin als Oxydationskatalysator, Skandinav. Arch. f. Physiol., 1929, lvi, 131. CrossrefGoogle Scholar2. ROEST J: Oxydationskatalyse durch Adrenalin, Biochem. Ztschr., 1926, clxxvi, 17. Google Scholar3. AHLGREN G: Quoted by Blix, l.c. Skandinav. Arch. f. Physiol., 1925, xlvii (Supp. vol.). Google Scholar4. BARCROFTDIXON JWE: The gaseous metabolism of the mammalian heart, Jr. Physiol., 1906/7, xxxv, 182. Google Scholar5. EVANSOGAVA CLS: The effect of adrenaline on the gaseous metabolism of the isolated mammalian heart, Jr. Physiol., 1914, xlvii, 466. Google Scholar6. GREMELS H: Ueber die Steuerung der energetischen Vorgänge am Froschherzen, Arch. f. exper. Path. u. Pharmakol., 1936, clxxxii, 1. CrossrefGoogle Scholar7. REIN H: Ueber Adrenalin, Verhandl. deutsch. Ges. f. Kreislaufforsch., 1937, x, 27. Google Scholar8. GOLLWITZER-MEIERKRAMERKRÜGER KKE: Die Wirkung des Adrenalins auf die Energetik des Herzens, Arch. f. d. ges. Physiol., 1936, ccxxxvii, 639. CrossrefGoogle Scholar9. BÜLBRING E: The action of adrenaline on transmission in the superior cervical ganglion, Jr. Physiol., 1944, ciii, 55. CrossrefGoogle Scholar10. CANNONROSENBLUETH WBA: Studies on conditions of activity in endocrine organs: sympathin E and sympathin I, Am. Jr. Physiol., 1933, civ, 557. CrossrefGoogle Scholar11. RAAB W: (a) The pathogenic significance of adrenalin and related substances in the heart muscle, Exper. Med. and Surg., 1943, i, 188. (b) Epinephrine and related substances in human arterial walls and kidneys, Arch. Path., 1943, xxxv, 836. (c) Roentgen treatment of the adrenal glands in angina pectoris (100 cases), Ann. Int. Med., 1940, xiv, 688. (d) Blood level of adrenalin and related substances in various experimental and clinical conditions, Exper. Med. and Surg., 1943, i, 402. (e) Abnormal suprarenal discharges in angina pectoris and their control by x-ray therapy, Jr. Clin. Endocrin., 1941, i, 977.* (f) Epinephrine tolerance of the heart altered by thyroxin and thiouracil, Jr. Pharmacol. and Exper. Therap., 1944, lxxxii, 330. (g) Sudden death of a young athlete with an excessive concentration of epinephrine-like substances in the heart muscle, Arch. Path., 1943, xxxvi, 388. (h) Sudden death with an excessive myocardial concentration of epinephrine-like substances in a case of obesity and cystic thyroid disease, Arch. Path., 1944, xxxviii, 110. (i) Cardiovascular effects of desoxycorticosterone acetate in man, Am. Heart Jr., 1942, xxiv, 365. (j) The hormonal, central and renal origin of "essential" hypertension (cerebral and renal arteriosclerotic ischemia as causal factors), Ann. Int. Med., 1941, xiv, 1981.* (k) Adrenocortical compounds* in the blood. Relation of their quantity to arterial hypertension, renal insufficiency and congestive heart failure, Arch. Int. Med., 1941, lxviii, 713. (l) Cardiotoxic substances in the blood and heart muscle in uremia (their nature and action), Jr. Lab. and Clin. Med., 1944, xxix, 715. (m) Arteriosklerose-Entstehung und Nebennierenlipoid-Adrenalin-Komplex, Ztschr. f. exper. Med., 1939, cv, 657. (n) Thiouracil treatment of angina pectoris. Rationale and results, Jr. Am. Med. Assoc., 1945, cxxviii, 249. (o) Diminution of epinephrine sensitivity of the normal human heart through thiouracil, Jr. Lab. and Clin. Med., 1945, xxx, 774. (p) _____ and HUMPHREYS, R. J.: Secretory function of sympathetic neurones and sympathin formation in effector cells, Am. Jr. Physiol., 1947, cxlviii, 460. *See footnote p. 1012. (q) _____: Drug action upon myocardial epinephrine-sympathin concentration and heart rate, Jr. Pharmacol. and Exper. Therap., 1947, lxxxix, 64. (r) _____: Protective effect of adrenolytic drugs against fatal myocardial epinephrine concentrations, Jr. Pharm. and Exper. Therap., 1946, lxxxviii, 268. (s) _____ and MAES, J. P.: Effect of sympathectomy without and with adrenal inactivation on the concentration of epinephrine and related compounds in various tissues, Am. Jr. Physiol., 1947, cxlviii, 470. (t) _____ and SCHÖNBRUNNER, E.: Die Normalisierungstendenz des Elektrokardiogrammes nebennierenbestrahlter Angina pectoris-Kranker, Arch. f. Kreislaufforsch., 1939, iv, 362. (u) _____ and SOULE, A. B., JR.: Effect of Roentgen irradiation on the hormone content of the adrenal medulla, Radiology, 1943, xli, 56. (v) _____: Rationale and results of Roentgen treatment of the adrenal glands in angina pectoris, Am. Jr. Roentgenol., 1944, li, 364. (w) _____ and SUPPLEE, G. C.: Cardiotoxic adreno-sympathetic activity in vitamin B deficiencies, Exper. Med. and Surg., 1944, ii, 152. Google Scholar12. BURNSCRUICKSHANK WEW: Changes in creatine, phosphagen and adenylpyrophosphate in relation to the gaseous metabolism of the heart, Jr. Physiol., 1937, xci, 314. CrossrefGoogle Scholar13. WEICKER B: Adrenalin und Tätigkeitsstoffwechsel des Warmblüterherzens, Arch. f. exper. Path. u. Pharmak., 1936, clxxxi, 525. CrossrefGoogle Scholar14. DECHERDHERRMANNERHARD GGP: The effect of myocardial destructive agents on the creatine content of the rabbit's heart, Proc. Soc. Exper. Biol. and Med., 1936, xxxiii, 519. CrossrefGoogle Scholar15. SCHUMANN H: (a) Die Verminderung des Glykogens, des Phosphagens und der Adenylpyrophosphorsäure im Herzmuskel bei Sauerstoffmangel und nach ermüdender Arbeit normaler und trainierter Tiere, Ztschr. f. exper. Med., 1939, cvi, 59. (b) Der Einfluss der männlichen Sexualhormone auf den Glykogen-, Phosphagen- und Adenylpyrophosphatgehalt des Herzmuskels, Klin Wchnschr., 1939, xviii, 925. (c) Untersuchungen über den Muskelstoffwechsel des Herzens, Ergebn. d. inn. Med. u. Kinderheilk., 1943, lxiv, 869. CrossrefGoogle Scholar16. COWAN DW: The creatine content of the myocardium of normal and of abnormal human hearts, Am. Heart Jr., 1934, ix, 378. CrossrefGoogle Scholar17. DECHERDBLUM GMJE: Phosphorus fractions in human heart muscle, Proc. Soc. Exper. Biol. and Med., 1938, xxxviii, 341. CrossrefGoogle Scholar18. HERRMANNDECHERD GGM: The chemical nature of heart failure, Ann. Int. Med., 1939, xii, 1233. Google Scholar19. LINEGARFROSTMYERS CRTTVC: Variation in creatine content of human cardiac and voluntary muscle at autopsy, Arch. Int. Med., 1938, lxi, 430. CrossrefGoogle Scholar20. MYERSMANGUN VCGH: Some chemical observations on the human heart in health and disease, Jr. Lab. and Clin. Med., 1940, xxvi, 199. Google Scholar21. WILKINSCULLEN WEGE: Electrolytes in human tissue. A comparison of normal hearts with hearts showing congestive heart failure, Jr. Clin. Invest., 1933, xii, 1063. CrossrefGoogle Scholar22. ROBERTSON WV: Changes in the distribution of electrolytes and water in cardiac muscle produced by epinephrine (in preparation). Google Scholar23. KATZWEINMAN LNSF: The relation of the T wave to the asynchronism between the ends of right and left ventricular ejection, Am. Jr. Physiol., 1927, lxxxi, 360. CrossrefGoogle Scholar24. LEPESCHKIN EW: (a) Das Elektrokardiogramm, 1946, Th. Steinkopff, Dresden und Leipzig. (b) Ueber das Elektrokardiogramm bei experimenteller Koronarinsuffizienz, Cardiologia, 1938, ii, 236. Google Scholar25. LEVINEERNSTENEJACOBSON ASACBH: The use of epinephrine as a diagnostic test for angina pectoris, Arch. Int. Med., 1930, xlv, 191. CrossrefGoogle Scholar26. VESA A: (a) Untersuchungen über die Einwirkung des Adrenalins auf das Elektrokardiogramm, Acta Soc. Med. Fennicae "Duodecim," 1938, xxvi, 5 (Helsinki). (b) Das Elektrokardiogramm im Arbeitsversuch nach Adrenalininjektion, ibidem, 1939, xxvi, 3. Google Scholar27. TWISSSOKOLOW AM: Angina pectoris, Am. Heart Jr., 1942, xxiii, 498. CrossrefGoogle Scholar28. WOODWOLFERTH FCCC: Angina pectoris. The clinical and electrocardiographic phenomena of the attack and their comparison with the effects of experimental coronary occlusion, Arch. Int. Med., 1931, xlvii, 339. CrossrefGoogle Scholar29. MAINZERKRAUSE FM: The influence of fear on the electrocardiogram, Brit. Heart Jr., 1940, ii, 221. CrossrefGoogle Scholar30. CANNON WB: Bodily changes in pain, hunger, fear and rage, 1929, Appleton & Co., New York and London. CrossrefGoogle Scholar31. KATZHAMBURGERLEV LNWWM: Diagnostic value of epinephrine in angina pectoris, Am. Heart Jr., 1932, vii, 371. CrossrefGoogle Scholar32. COTTRELLWOOD JEFC: Effect of epinephrine in angina pectoris, Am. Jr. Med. Sci., 1931, clxxxi, 36. CrossrefGoogle Scholar33. WENCKEBACH KF: Herz- und Kreislaufinsuffizienz, 1932, Th. Steinkopff, Dresden. Google Scholar34. KOBRO MS: Nikotinwirkung und Adrenalinsekretion, 1936, Johan Grundt Tanum, Oslo. Google Scholar35. EICHHOLTZ F: Ueber den Einfluss von Nikotin und nikotinartig wirkenden Substanzen auf die Adrenalinsekretion, Arch. f. exper. Path. u. Pharmak., 1923, xcix, 172. CrossrefGoogle Scholar36. CANNONAUBBINGER WBJCCA: Note on effect of nicotine injection on adrenalin secretion, Jr. Pharm. and Exper. Therap., 1911/12, iii, 379. Google Scholar37. DENEKE T: Tabak und Angina pectoris, Ztschr. f. ärztl. Fortbild., 1936, xxxiii, 573. Google Scholar38. LABARREHOUSSA JP: À propos des variations de l'adrénalinémie au cours de l'hypoglycémie insulinique, Compt. rend. Soc. d. biol., 1932, cix, 967. Google Scholar39. KUGELMANN B: Zur Frage der Adrenalinausschüttung bei der Insulinhypoglykämie und bei Pal'schen Gefässkrisen, Klin. Wchnschr., 1933, xii, 1488. CrossrefGoogle Scholar40. BRANDTKATZ FG: Ueber den Nachweis von Adrenalinsekretion beim Menschen, Ztschr. f. klin. Med., 1933, cxxiii, 40. Google Scholar41. SCHOU HJ: Complications concerning shock therapy, Acta physiol. et neurol., 1942, xvii, 277. Google Scholar42. GRALNICH A: Pulmonary edema and EKG findings resembling coronary occlusion in insulin treatment, Psychiat. Quart., 1944, xviii, 650. CrossrefGoogle Scholar43. GILBERTGOLDZIEHER RAJW: The mechanism and prevention of cardiovascular changes due to insulin, Ann. Int. Med., 1946, xxv, 928. Google Scholar44. NUZUMDALTON FRJW: Paroxysmal and persistent hypertension in association with lesions of adrenal glands, Am. Heart Jr., 1938, xvi, 643. CrossrefGoogle Scholar45. BRUNSCHWIGHUMPHREYSROOME AENW: Relief of paroxysmal hypertension by excision of pheochromocytoma, Surgery, 1938, iv, 361. Google Scholar46. LENHARTZ H: Ueber paroxysmale Blutdrucksteigerungen, Klin. Wchnschr., 1939, xviii, 109. Google Scholar47. RATNOFFPLOTZ ODM: The coronary circulation, Medicine, 1946, xxv, 285. CrossrefGoogle Scholar48. TILMANN O: Chromaffiner Tumor als Todesursache, Beitr. z. path. Anat. u. z. allg. Path., 1935, xcv, 60. Google Scholar49. PAUL F: Die krankhafte Funktion der Nebenniere und ihr gestaltlicher Ausdruck, Virchow's Arch. f. path. Anat., 1931, cclxxxii, 256. CrossrefGoogle Scholar50. WICKENHÄUSER K: Der plötzliche oder ziemlich plötzliche Tod bei Nebennierenmarktumoren und seine Bedeutung für die gerichtliche Medizin, Deutsch. Ztschr. f. gerichtl. Med., 1939, xxxi, 97. Google Scholar51. MINOVICIBONCIU NC: La mort subite dans un cas de paragangliome surrénal bilatéral, Bull. Acad. de méd. de Roumanie, 1936, i, 638. Google Scholar52. HOLTZ E: Plötzlicher Tod bei Phäochromozytom der Nebenniere, Deutsch. Ztschr. f. d. ges. gerichtl. Med., 1939, xxxii, 94. Google Scholar53. SIMPSON CK: Pathology of the adrenal gland in relation to sudden death, Lancet, 1937, i, 851. CrossrefGoogle Scholar54. KRUSE WE: A statistical analysis of 1700 sudden and violent deaths, Jr. Indiana Med. Assoc., 1940, xxxiii, 509. Google Scholar55. SEVERN AG: Acute bilateral suprarenal hemorrhage, Lancet, 1923, i, 647. CrossrefGoogle Scholar56. HENDERSONPETTIGREW JAF: Sudden death from hemorrhage into suprarenal capsules in a child, Brit. Med. Jr., 1932, i, 14. Google Scholar57. DAMON LA: Bilateral suprarenal hemorrhage as cause of sudden death in epilepsy, Psychiat. Quart., 1932, vi, 438. CrossrefGoogle Scholar58. FISHER RS: Personal communication (Harvard Medical School, Dept. of Legal Medicine). Google Scholar59. MARKOWITZ B: Sudden death. A neurocirculatory disturbance, Am. Jr. Clin. Path., 1942, xii, 276. CrossrefGoogle Scholar60. BOHRAD : Quoted by Markowitz, l.c. Google Scholar61. Brisard C: La mort subite préopératoire, Ann. de méd. lég., 1937, xvii, 1057. Google Scholar62. MARTINROYO VILLANOVA Y MORALES ER: Muerte imprevista y "shock" emocional, Siglo Méd., 1929, lxxxiii, 485. Google Scholar63. STEFAN H: Ueber den plötzlichen natürlichen Tod infolge hochgradiger Erregung bei akuten Psychosen ohne wesentliche anatomisch nachweisbare Ursache, Ztschr. f. d. ges. Neurol. u. Psychiat., 1935, cvii, 480. CrossrefGoogle Scholar64. LEVYBRUENN RLHG: Acute fatal coronary insufficiency, Jr. Am. Med. Assoc., 1936, cvi, 1080. CrossrefGoogle Scholar65. BRACKPLASSMANNKRÜGER EKE: Ueber den Zusammenhang zwischen plötzlichem Tode, Herzhypertrophie und Nebennierenveränderungen, Ztschr. f. Kreislaufforsch., 1930, xxii, 210. Google Scholar66. WEYRICH G: Erfahrungen über den plötzlichen Tod aus innerer Ursache bei Kindern und Jugendlichen, Deutsch. Ztschr. f. d. ges. gerichtl. Med., 1933, xxii, 116. Google Scholar67. KITCHIN DH: Sudden death at work, Med. Legal and Criminol. Revue, 1934, ii, 195. CrossrefGoogle Scholar68. MARRADI-FABRONI S: L'affaticamento, il fattore tossico e morboso nella dottrina della morte apparenti e improvvise, Riforma med., 1934, l, 999. Google Scholar69. BÖHMIG R: Plötzliche Todesfälle bei Jugendlichen der Wehrmacht und des Reichsarbeitsdienstes, Med. Klin., 1940, xxxvi, 209. Google Scholar70. MANGILI C: Sport e morte improvvisa, Arch. di antropol. crim., psichiatr. e med. leg., 1937, lvii, 694. Google Scholar71. FRENCHDOCK AJW: Fatal coronary arteriosclerosis in young soldiers, Jr. Am. Med. Assoc., 1944, cxxiv, 1233. CrossrefGoogle Scholar72. MORITZZAMCHECK ARN: Sudden and unexpected death of young soldiers, Arch. Path., 1947, xlii, 459. Google Scholar73. STEPPUHNNAUMOVAUGAROVA ONN: Chemical and pharmacodynamic characteristics of the heart in hyperthyroidism, Klinicheskaya Meditsina, 1935, xiii, 1265 (Russian). Google Scholar74. WISEHOFF BHE: The effect of autonomic hormones on the thyrotoxic heart, Jr. Pharm. and Exper. Therap., 1938, lxvi, 217. Google Scholar75. AUMANNYOUMANS KWWB: Differential sensitization of adrenergic neuro-effector system by thyroid hormone, Am. Jr. Physiol., 1940, cxxxi, 394. CrossrefGoogle Scholar76. SAWYERBROWN MEMG: Effect of thyroidectomy and thyroxin on the response of the denervated heart to injected and secreted adrenine, Am. Jr. Physiol., 1935, cx, 620. Google Scholar77. SADAE O: On the sensitizing action of thyroid extract for adrenalin, Jap. Med. World, 1922, ii, 157. Google Scholar78. LÜTOLF W: Untersuchungen über die Sensibilisierung von Adrenalin durch Thyroxin am überlebenden Säugetierherzen, Ztschr. f. Biol., 1930, xc, 334. Google Scholar79. WEISSWILKINS SRW: The nature of the cardiovascular disturbances in vitamin deficiency states (beriberi), Ann. Int. Med., 1937, xi, 104. LinkGoogle Scholar80. MEANSHERTZLERMAN JHSJ: Nutritional factors in Graves' disease, Ann. Int. Med., 1937, xi, 429. Google Scholar81. LIKOFFLEVINE WBSA: Thyrotoxicosis as the sole cause of heart failure, Am. Jr. Med. Sci., 1943, ccvi, 425. CrossrefGoogle Scholar82. WILLIAMSEGANAROBINSONASPERDUTOIT RHEPSPC: Alterations in biologic oxidation in thyrotoxicosis, Arch. Int. Med., 1943, lxxii, 353. CrossrefGoogle Scholar83. SÁRFY E: Adrenalin in Nebennieren und Blut B1-avinaminotischer Tauben und Ratten, Ztschr. f. physiol. Chem., 1939, cclxii, 87. Google Scholar84. DUSTINWEYLERROBERTS CCHCP: Electrocardiographic changes in vitamin B1-deficiency, New Eng. Jr. Med., 1939, ccxx, 15. CrossrefGoogle Scholar85. DE SOLDATI L: Los trastornos circulatorios del perro en avitaminosis B1 , Rev. Soc. Argent. de biol., 1939, xv, 142. Google Scholar86. WEISSHAYNESZOLL SFWPM: Electrocardiographic manifestations and the cardiac effect of drugs in vitamin B1 deficiency in rats, Am. Heart Jr., 1938, xv, 206. CrossrefGoogle Scholar87. SWANKPORTERYEOMANS RLRRA: The production and study of cardiac failure in thiamin deficient dogs, Am. Heart Jr., 1941, xxii, 154. CrossrefGoogle Scholar88. WINTROBEALCAYAGAHUMPHREYSFOLLIS MMRSRH: Electrocardiographic changes associated with thiamin deficiency in pigs, Bull. Johns Hopkins Hosp., 1943, lxxiii, 169. Google Scholar89. WENCKEBACH KF: Das Beriberi-Herz, 1934, J. Springer, Berlin. CrossrefGoogle Scholar90. PORTODE SOLDATI JL: Alteraciones microscopicas del corazon del perro en avitaminosis B1 , Rev. Soc. Argent. de biol., 1939, xv, 303. Google Scholar91. VAN ETTENELLISMADSEN CNRLL: Studies on the thiamin requirement, Jr. Nutr., 1940, xx, 607. CrossrefGoogle Scholar92. FOLLISMILLERWINTROBESTEIN RHMHMMHJ: Development of myocardial necrosis and absence of nerve degeneration in thiamin deficiency in pigs, Am. Jr. Physiol., 1943, xix, 341. Google Scholar93. ASHBURNLOWRY LLJV: Development of cardiac lesions in thiamin deficient rats, Arch. Path., 1944, xxxvii, 27. Google Scholar94. WEISS S: Occidental beriberi with cardiovascular manifestations, Jr. Am. Med. Assoc., 1940, cxv, 832. CrossrefGoogle Scholar95. MARTINLISSÁK JK: Acetylcholinempfindlichkeit und Vitamin B1 , Arch. f. exper. Path. u. Pharm., 1941, cxcviii, 667. CrossrefGoogle Scholar96. BEZNAKPERJES AJ: Die Beziehung der Nebennierenrindenhypertrophie zu Muskelarbeit und Vitamin B-Gehalt der Nahrung, Arch. f. d. ges. Physiol., 1935, ccxxxvi, 181. CrossrefGoogle Scholar97. LOCKWOODHARTMAN JAFA: Relation of the adrenal cortex to vitamins A, B and C, Endocrin., 1933, xvii, 501. CrossrefGoogle Scholar98. GOODSELL JE: Weight changes in the cortex and the medulla of the adrenal gland of the dog in acute vitamin B1 deficiency, Am. Jr. Physiol., 1941, cxxxiv, 119. CrossrefGoogle Scholar99. CASTLEMANSMITHWICK BRH: The relation of vascular disease to hypertensive state, Jr. Am. Med. Assoc., 1943, cxxi, 1256. CrossrefGoogle Scholar100. GREGORYEWINGLEVINROSS RPLWCGT: Studies on hypertension. IV. Bioassay of vasoconstrictor substances in ultrafiltrates of citrated blood plasma from patients with normal blood pressures, patients with essential hypertension and patients made hypertensive by intravenous injection of angiotonin (hypertensin), Arch. Int. Med., 1945, lxxvi, 11. Google Scholar101. treatment of hypertension, Arch. Surg., 1944, CrossrefGoogle The and effects of and sympathectomy on blood Ann. Surg., 1937, cvi, CrossrefGoogle concerning the nature of hypertension, New Eng. Jr. Med., 1939, ccxx, CrossrefGoogle The production of hypertension in by of the Jr. Lab. and Clin. Med., 1943, 1. Google AM: and in arterial hypertension, Am. Heart Jr., 1930, CrossrefGoogle The in hypertension, Am. Heart Jr., 1945, xxx, CrossrefGoogle The in hypertension, Am. Heart Jr., 1945, xxx, CrossrefGoogle in hypertension, Jr. Am. Med. Assoc., 1946, cxxxi, CrossrefGoogle The and in hypertension, Bull. Med. and 1941, iv, 116. Google The in hypertension, Am. Heart Jr., 1945, xxx, CrossrefGoogle of muscle in suprarenal in hypertension, Arch. Path., 1. Google The suprarenal glands and hypertension, Ann. Int. Med., 1930, iii, Google O: Compt. rend. Soc. biol., 285. Google Ueber die der bei Virchow's Arch. f. path. Anat., CrossrefGoogle L: Untersuchungen über die von Berlin. klin. Wchnschr., and Google Ueber f. Path., xx, 104. Google a study of the changes intravenous of adrenalin, Jr. Exper. Med., CrossrefGoogle G: von Virchow's Arch. f. path. Anat., 1937, CrossrefGoogle und im an von Virchow's Arch. f. path. Anat., 1926, med. Wchnschr., ii, Google MS: des Herz- und med. Wchnschr., 1922, and Google E: Ueber die Wirkung von Adrenalin und und am Arch. exper. Path. u. Pharmak., 1938, 657. CrossrefGoogle Effect of and desoxycorticosterone on the heart, Proc. Soc. Exper. Biol. and Med., 1944, CrossrefGoogle Das Zur der Ztschr. f. klin. Med., 1938, cxxxiv, Google G: der f. Path., 1937, Google R: Zur der 1938, J. Grundt Tanum, Oslo. Google The inactivation of adrenaline in in man, Jr. Physiol., 1940, 361. CrossrefGoogle The of epinephrine related Am. Jr. Physiol., 1945, CrossrefGoogle The in uremia and with Am. Jr. Med. Sci., 1925, CrossrefGoogle E: (a) über die der inn. Med., 1925, (b) und der d. ges. Med., 1933, xviii, Google The myocardial degeneration associated with uremia in hypertensive disease and Am. Jr. Med. Sci., 1940, CrossrefGoogle e e 1939, xxiii, Google Electrocardiographic changes in associated with Am. Heart Jr., 1946, xxxi, CrossrefGoogle W: Ueber Ztschr. f. Path., 1922, xxvi, by Google The heart in Am. Jr. Path., 1942, xviii, Google F: der in der Medizin, by and Google : de méd. by and Google The concentration of creatine in heart, and muscle in Ann. Int. Med., 1942, xvi, Google The cause of death in experimental Jr. Clin. Invest., 1941, xx, 607. CrossrefGoogle Fatal in patients with Arch. Int. Med., 1944, lxxiii, CrossrefGoogle Electrocardiographic changes in uremia associated with a high concentration of Am. Heart Jr., 1944, CrossrefGoogle F: e di 1937, Google R: Relation between the of uremia and the blood of the Arch. Int. Med., 1942, CrossrefGoogle F: Die in Bedeutung für die des Beitr. z. path. Anat. u. allg. Path., Google W: and sudden death of the Arch. Path., 1945, Google des de de Ann. 1936, xiii, Google Arch. de 1933, xxxv, Google changes in various by with Arch. Path., 1943, xxxvi, Google changes in of desoxycorticosterone Jr. Clin. Endocrin., 1946, vi, CrossrefGoogle Verhandl. d. deutsch. Ges. f. Kreislaufforsch., 1932, Google The heart in hypertensive Am. Google W: (a) Untersuchungen des im Arch. f. Kreislaufforsch., 1937, ii, (b) der Angina pectoris, 1937, 285. CrossrefGoogle A: der von und Nebenniere, 1939, lxvi, Google O: Zur und der Angina pectoris, med. Wchnschr., 1940, Google : 1944, G. p. Google of the adrenal cortex associated with essential hypertension, Arch. Path., 1941, xxxii, 169. Google of the adrenal cortex in hypertension and Arch. Int. Med., 1945, lxxvi, CrossrefGoogle heart failure and angina effect of thyroidectomy on patients without clinical or of thyroid Arch. Int. Med., 1933, li, CrossrefGoogle of thyroidectomy in heart disease, New Jr. Med., 1937, CrossrefGoogle thyroidectomy for heart disease, New Jr. Med., 1936, 277. CrossrefGoogle S: (a) The treatment of with thiouracil, Jr. Med. Soc. New 1945, xlii, (b) observations on the treatment of the with thiouracil, Am. Heart Jr., 1947, xxxiii, Google of treatment of angina pectoris, Am. Heart Jr., 1946, xxxii, CrossrefGoogle Thiouracil of activity for the treatment of hyperthyroidism, Jr. Clin. 1945, CrossrefGoogle G: Untersuchungen Wirkung von Adrenalin auf den Arch. f. Kreislaufforsch., 1940, vi, CrossrefGoogle R: Die der beim des Med. Klin., 1938, 17. Google E: Die durch und über die Wirkung 1937, Google H: Zur med. Wchnschr., 1939, lxxxix, Google of and in cardiovascular disease, Med. and 1940, 667. Google of angina pectoris and coronary disease with Med. Jr., 1941, xxxvii, Google (a) of angina pectoris with New Jr. Med.