Biochemical screening of pyrimidine antimetabolites. III. The testing of drugs against a system with a non-oxidative energy source.

Abstract

Summary Seventeen drugs which demonstrated in vitro inhibitory activity against an oxidative system for the conversion of orotic acid to the uridine nucleotides were retested against a nonoxidative system. The 5-bromo, 5-chloro and 5-fluoro analogs of orotic acid were demonstrated to produce single or multiple blocking actions against this system.