Activation of <scp>P2Y₆</scp> receptors increases the voiding frequency in anaesthetized rats by releasing <scp>ATP</scp> from the bladder urothelium

Abstract

Activation of P2Y6 receptors increased the voiding frequency indirectly by releasing ATP from the urothelium and activation of P2X3 receptors on sub-urothelial nerve afferents. Bladder hyperactivity may be partly reversed following ATP hydrolysis to ADP by E-NTPDases, thereby decreasing ACh release from cholinergic nerves expressing P2Y1 receptors.