Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant‐induced arthritis model: a translational study

Abstract

This multiparametric approach can reveal specific drug properties and provide translational information. Whereas the complex profile for p38 inhibition in AIA is not observed in human RA, immunosuppressants such as DHODH and JAK inhibitors show DMARD properties and side effects seen in both AIA and RA.