Papilloma-like virus from bovine urinary bladder tumors.

Abstract

Summary Suspensions of 6 spontaneous bovine urinary bladder tumors produced fibropapillomas of the skin and vagina as well as polypoid growths with fibroma in the urinary bladders of test calves. The induction period ranged from 25 to 111 days. Three serial animal passages of one isolate which was filterable did not increase the activity of the virus. The infective agent resembles the bovine wart virus in its behavior in test calves and may be a causative factor in the etiology of spontaneous bladder tumors or it might simply be a passenger virus. Material from 10 other spontaneous bovine urinary bladder tumors were inactive.