The Enzymatic Conversion of Uracil 5-Carboxylic Acid to Uracil and Carbon Dioxide

Abstract

The enzymatic decarboxylation of uracil 5-carboxylic acid has been demonstrated. A partially purified enzyme preparation has been obtained from Neurospora crassa which stoichiometrically converts uracil 5-carboxylic acid to uracil and carbon dioxide. No cofactor requirement for uracil 5-carboxylic acid decarboxylase activity was detected.