Macrophage Migration Inhibitory Factor Receptor CD74 Mediates Alphavirus‐Induced Arthritis and Myositis in Murine Models of Alphavirus Infection

Abstract

CD74 appears to regulate immune responses to alphaviral infection through its effects on cellular recruitment and survival. These findings suggest that both MIF and CD74 play a critical role in mediating alphaviral disease, and blocking these factors with novel therapeutic agents could substantially ameliorate the pathologic manifestations.