The effect of CYP3A inhibitors and inducers on the pharmacokinetics of telaprevir in healthy volunteers

Abstract

CYP3A inducers, rifampicin and efavirenz, can reduce telaprevir exposure to varying degrees based on their potency. The effect of ketoconazole as an inhibitor of telaprevir metabolism is more pronounced after a single dose of telaprevir than after repeated administration.