INCIDENCE AND SIGNIFICANCE OF SEROPOSITIVE TESTS FOR RHEUMATOID FACTOR IN NONRHEUMATOID DISEASES

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Article1 May 1960INCIDENCE AND SIGNIFICANCE OF SEROPOSITIVE TESTS FOR RHEUMATOID FACTOR IN NONRHEUMATOID DISEASESHARRY BARTFELD, M.D.HARRY BARTFELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-5-1059 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur laboratory and others using various technics for demonstrating "rheumatoid arthritis factor" have found impressive numbers of seropositives in nonrheumatoid, noncollagen diseases. Miller et al.6 in 1949, and Craig et al.20 in 1957, inferred that the sensitized sheep cell test was not diagnostic of any specific disease entity. Dresner30, a, b in 1958 and 1959 performed extensive studies with the Fraction II Latex Fixation Test, and feels that the rheumatoid agglutinating factor is not specific.It should be remembered that Meyer1in 1922 found that a serum of a cirrhotic patient strongly agglutinated sheep and guinea pig cells sensitized with...Bibliography1. Meyer K: Ueber Hämagglutininvermehrung und Hämagglutination fordernde Wirkung bei menschlichen Seren, Ztschr. f. Immunitätsforsch. u. exper. Therap. 34: 229, 1922. Google Scholar2. Waaler E: On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles, Acta path. et microbiol. scandinav. 17: 172, 1940. CrossrefGoogle Scholar3. RoseRaganPearceLipman HMCEMO: Differential agglutination of normal and sensitized sheep erythrocytes by sera of patients with rheumatoid arthritis, Proc. Soc. Exper. Biol. and Med. 68: 1, 1948. CrossrefMedlineGoogle Scholar4. 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Y.*Received for publication January 25, 1960.From the Department of Medicine and the Rheumatic Diseases Study Group, New York University-Bellevue Medical Center.Requests for reprints should be addressed to Harry Bartfeld, M.D., Associate Professor of Clinical Medicine, The New York University Post-graduate Medical School, 550 First Avenue, New York 16, N. Y. 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