<scp>C</scp>‐reactive protein promotes atherosclerosis by increasing <scp>LDL</scp> transcytosis across endothelial cells

Abstract

CRP promoted atherosclerosis by directly increasing the transcytosis of LDL across endothelial cells and increasing LDL retention in vascular walls. These actions of CRP were associated with generation of reactive oxygen species, activation of PKC and Src, and translocation of caveolar or soluble forms of the N-ethylmaleimide-sensitive factor attachment protein.