THE EFFECT OF PITUITARY ADRENOCORTICOTROPIN (ACTH) IN DERMATOMYOSITIS

Abstract

Case Reports1 February 1950THE EFFECT OF PITUITARY ADRENOCORTICOTROPIN (ACTH) IN DERMATOMYOSITIST. W. OPPEL, M.D., F.A.C.P., CAROLYN COKER, M.D., A. T. MILHORAT, M.D.T. W. OPPEL, M.D., F.A.C.P.Search for more papers by this author, CAROLYN COKER, M.D.Search for more papers by this author, A. T. MILHORAT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-2-318 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the report that an adrenal cortical hormone induces clinical improvement in the symptoms of rheumatoid arthritis,1it has been suggested that other diseases with extensive involvement of collagen tissue might be similarly benefited. A supply of adrenocorticotropin (ACTH-Armour†) was made available to us for study in dermatomyositis and two patients have been treated. One patient who suffered also from advanced carcinomatosis received no apparent benefit from 12 days of treatment, but the effect on the other patient was dramatic. Improvement began within a few hours after the first dose, and the patient was transformed from a critical state into...Bibliography1. HenchKendallSlocumbPolley PSECCHHF: The effect of a hormone of the adrenal cortex (17 hydroxy 11 dehydrocorticosterone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis; preliminary report, Proc. Staff Meet., Mayo Clin. 24: 181, 1949. MedlineGoogle Scholar2. ForshamThornPruntyHills PHGWFTAG: Clinical studies with pituitary adrenocorticotropin, J. Clin. Endocrinol. 8: 15, 1948. CrossrefMedlineGoogle Scholar3. ThornForshamPruntyHills GWPHFTAG: A test for adrenal cortical insufficiency, J. A. M. A. 137: 1005, 1948. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N.Y.*Received for publication November 25, 1949.From the Departments of Medicine and Psychiatry, Cornell University Medical College, The New York Hospital, and the Russell Sage Institute of Pathology, New York.Aided by the Armour Fund for Research in Muscular Diseases and by a grant from the Nutrition Foundation, Inc.†The authors are indebted to John R. Mote, M.D., Medical Director, the Armour Laboratories, Chicago, Illinois, for the ACTH used in these studies. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntroduction to MyositisCorticosteroid use in the treatment of neuromuscular disorders: Empirical and evidence-based dataPolymyositis-dermatomyositisDie Biochemie der progressiven MuskeldystrophieDermatomyositisDermatomyositisNeuromuscular disorders associated with malignant neoplastic diseaseDas adrenocorticotrope Hormon (ACTH), die HormonederNebenniere(Cortison,Adrenalin) das Insulin, sowie die Hormone der Schilddrüse und NebenschilddrüseSTEROID THERAPY IN COLLAGEN DISEASES. *FUNDUS APPEARANCES IN A CASE OF ACUTE DERMATOMYOSITISDie Steroid-Therapie rheumatischer ErkrankungenDermatomyositis und CarcinomDermatomyositisDermatomyositis in ChildhoodThe Effect of Cortisone in PolymyositisRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.THE NEUROLOGICAL ASPECTS OF DERMATOMYOSITISKlinische Beobachtungen bei der Cortison- und ACTH-Behandlung von DermatosenTHE REVERSIBILITY OF CERTAIN RHEUMATIC AND NONRHEUMATIC CONDITIONS BY THE USE OF CORTISONE OR OF THE PITUITARY ADRENOCORTICOTROPIC HORMONE*PHILIP S. HENCH, M.D., F.A.C.P.Acth and cortisone in pediatric practiceThe effect of adrenalectomy on experimental hypersensitivenessThe Clinical Usefulness of ACTH and Cortisone 1 February 1950Volume 32, Issue 2Page: 318-324KeywordsAdrenocorticotropic hormoneCarcinomatosisCollagen diseasesDermatomyositisHormonesHospital medicineMuscular diseasesNutritionResearch funding ePublished: 1 December 2008 Issue Published: 1 February 1950 PDF downloadLoading ...