Indomethacin produces gastric antral ulcers in the refed rat

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

Cytoprotection by prostaglandins

André Robert · Gastroenterology · 1979 · 1.1K citations

Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat

Brendan J.R. Whittle · Gastroenterology · 1981 · 441 citations

Medicine, Pharmacology, Pharmacodynamics +10

Small intestinal ulcers and intestinal flora in rats given indomethacin.

Thomas H. Kent, R Cardelli, Frederic W. Stamler · PubMed · 1969 · 296 citations

Medicine, Pharmacotherapy, Gastrointestinal Pharmacotherapy +11

An Intestinal Disease Produced Experimentally by a Prostaglandin Deficiency

A. Robert · Gastroenterology · 1975 · 213 citations · Full text

Medicine, Pathobiology, Pathology +10