The effects of moclobemide on the pharmacokinetics of the 5‐HT_1B/1D agonist rizatriptan in healthy volunteers

Abstract

Moclobemide inhibited the metabolism of rizatriptan and its active N-monodesmethyl metabolite through inhibition of MAO-A. Thus, moclobemide may considerably potentiate rizatriptan action. Concurrent administration of moclobemide and rizatriptan is not recommended.