Detection of Osteoprotegerin and TNF‐alpha mRNA in Ankylotic Stapes Footplates in Connection With Measles Virus Positivity

Abstract

Detection of TNF-alpha mRNA demonstrates activated osteoclast functions and inflammatory pathways in otosclerotic stapes footplates associated with measles virus presence. Increased expression of TNF-alpha and its action on RANK production inhibits the protective functions of osteoprotegerin on normal bone turnover in the otic capsule.