Epigenetic silencing of <i>CHD5</i>, a novel tumor‐suppressor gene, occurs in early colorectal cancer stages

Abstract

The CHD5 gene is repressed in all types of adenomas, either epigenetically or by chromosomal deletion. CHD5 activity is regulated by DNA methylation and repressive histone modifications. CHD5 likely acts as a tumor-suppressor gene in early colorectal carcinogenesis.