Frequencies of <i>CYP2D6</i> mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan <i>O</i>‐demethylation in different <i>CYP2D6</i> genotypes

Abstract

CYP2D6*5 and CYP2D6*14 are the major defective alleles found in Japanese subjects. In addition, CYP2D6*10 may play a more important role than previously thought for the treatment of Japanese patients with drugs metabolized by CYP2D6.