Studies of aggregated gamma-globulin. I. Sedimentation, electrophoretic and anticomplementary properties.

Abstract

Summary Molecular aggregation occurs when solutions of γ-globulin are heated to 56°C. Aggregated γ-globulin, when concentrated by salt fractionation, demonstrated marked anticomplementary properties. Preliminary C′ studies suggested that absorption of guinea pig serum with solid γ-globulin resulted in C′ component destruction that resembled C′ inactivation by immune systems.