Hydroxyurea: inhibition of deoxyribonucleic acid synthesis in regenerating liver of rats.

Abstract

Summary Single, nonlethal doses of hydroxyurea are rapidly inhibitory to the incorporation of thymidine-2- 14 C and phosphate- 32 P into DNA 2 of regenerating liver of the rat. The agent does not affect synthesis or sedimentation profiles of RNA, and it is not cytotoxic to liver under the conditions tested.