Hypertension and the absence of EDHF‐mediated responses favour endothelium‐dependent contractions in renal arteries of the rat

Abstract

In the renal artery of the rat, EDCF-mediated contractions are augmented by hypertension. The endothelium-dependent contractions are facilitated by NOS inhibition (in the presence of an EP-1 receptor antagonist) and by the withdrawal of EDHF-mediated responses.