The role of the regional lymph nodes in the immunity to a chemically induced sarcoma in C3H mice.

Abstract

Summary The functional significance of the host9s regional lymphoid tissues in the immunity to chemically induced tumors was studied in inbred C3H/HeN female mice using a 20-methylcholanthrene-induced sarcoma in its second and third transplant generations. Unilateral removal of the regional lymphoid tissues did not significantly alter host response to a primary chemically induced tumor cell inoculum injected either distal to the lymphadenectomy or in the contralateral hind limb. A regional lymphadenectomy had no effect on the growth of an established chemically induced tumor transplant, nor did it significantly alter an immunized host9s response to a subsequent challenge with the same chemically induced tumor. Adoptive transfer of immunity to a chemically induced tumor was accomplished with regional lymph node cells from tumor-bearing animals when 10 8 cells were administered intraperitoneally to previous untreated recipients.