Anti‐atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase‐1

Abstract

Atherosclerosis induced an endothelial [NO]/[ONOO(-)] balance indicative of endothelial dysfunction. Statins showed anti-atherosclerotic effects mediated by HO-1/eNOS, restoring the [NO]/[ONOO(-)] imbalance and reducing lipid peroxidation.