Publication | Open Access
Conceptual and methodologic challenges of assessing the short-term efficacy of Guggulu in obesity: data emergent from a naturalistic clinical trial.
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2000
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NutritionBariatric SurgeryNaturalistic Clinical TrialPublic Health NutritionWeight ManagementShort-term EfficacyObesity PreventionObesityMetabolic SyndromeBody CompositionBody Mass IndexHealth SciencesClinical NutritionObesity ManagementMedical Nutrition TherapyWeight LossMethodologic ChallengesGlobal HealthDiabetesOpen Comparative TrialMedicine
An open comparative trial was conducted in 58 adult obese patients (Body Mass Index > or = 25 kg/square metre). Group I (n = 27), non-drug, was advised diet (1200-1600 cals) and a brisk walk for 30 minutes. Group II, in addition, received Guggulu (Medohar) 1.5-3 gms/day for 30 days. Mean difference in weight loss between Guggulu and non-drug group was 0.32 kg (ns) on day 15 and 0.58 kg on day 30 (ns). The mean weight reduction in patients (> 90 kgs) was 1.92 kg (ns) and 2.25 kg (ns) higher in Guggulu group. All patients weighing > 90 kg lost weight in Guggulu group whilst 3 in non-drug group did not lose weight. Guggulu was tolerated well. The data from this pilot study suggest a synergistic diet-Guggulu interaction over 30 days in patients weighing > 90 kgs which needs to be confirmed in a large placebo controlled study.