Succinic half‐esters of poly(ethylene glycol)s and their benzotriazole and imidazole derivatives as oligomeric drug‐binding matrices

Abstract

Abstract α‐Hydroxysuccinyl‐ω‐hydroxysuccinyloxypoly(oxyethylene)s (succinic half‐esters of poly‐(ethylene glycol)s) ( 2 ) of different molecular weights were prepared, and transformed into the corresponding benzotriazole and imidazole derivatives 3 and 4 . The benzotriazolyl or the imidazolyl residues in these polymers can easily be exchanged. This was proved with model compounds bearing hydroxyl or amino groups. Polymers of this type may be considered as potential oligomeric drug‐binding matrices.