CARBON DIOXIDE TOLERANCE STUDIES

Abstract

Abstract : Seven normal volunteers were exposed to an environment of 21 mm. Hg CO2 (3%) for a 5-day experimental period bracketed by two 5-day control periods. Measurements included daily serum and urine electrolytes, blood gas studies, and net acid excretion studies. Also included were detailed investigations of respiratory physiology, exercise response, and psychomotor performance. All subjects tolerated the experimental atmosphere with no undue problems. Arterial and alveolar PCO2's increased 3 to 4 mm. Hg with a mild reduction in arterial pH from 7.40 to 7.37. Arterial pH values returned to near control values by the fourth day. No increases were noted in net acid excretion. Exercise was tolerated remarkably well.