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Stereoselective reactions. X. Total synthesis of optically pure antitumor lignan, burseran.
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1985
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Medicinal ChemistryEnantioselective SynthesisBioorganic ChemistryEngineeringGas ChromatographyUnequivocal MannerNatural SciencesTotal SynthesisOrganic ChemistryPure Antitumor LignanSynthetic ChemistryStereoselective SynthesisPharmacologyRadiation OncologyAntitumor LignanStereoselective ReactionsBiomolecular EngineeringNatural Product Synthesis
Optically pure trans- and cis-burseran (4, 10) were stereoselectively synthesized in an unequivocal manner. Comparison of their behaviors on gas chromatography indicated that naturally occurring antitumor lignan, burseran, is the trans-isomer.