Studies on the constituents of Veratrum plants. II. Constituents of Veratrum nigrum L. var. ussuriense. (1). Structure and 1H- and 13C-nuclear magnetic resonance spectra of a new alkaloid, verussurinine, and related alkaloids.

Abstract

Alkaloidal constituents of the roots and rhizoma of Veratrum nigrum L. var. ussuriense (Liliaceae), which are used as a source of the Chinese crude drug "Li-lu, " were examined and a new alkaloid named verussurinine and six known alkaloids have been isolated. The structure of verussurinine was determined to be 16-O-(2-methylbutyroyl)germine (1) by means of spectroscopic methods, and six other alkaloids were identified as germidine (2), germerine (3), 15-O-(2-methylbutyroyl)germine (4), verazine (5), jervine (6), and neogermbudine (7), Complete assignments of the proton and carbon-13 nuclear magnetic resonance (1H- and 13C-NMR) signals of these alkaloids are also presented.