Fe(OTf)₃‐Catalyzed Aromatization of Substituted 3‐Methyleneindoline and Benzofuran Derivatives: A Selective Route to C‐3‐Alkylated Indoles and Benzofurans

Abstract

Abstract A simple and convenient approach was developed to the selective synthesis of 3‐substituted indoles and benzofurans by the isomerization of 3‐methyleneindoline and benzofuran derivatives catalyzed by Fe(OTf) 3 . The salient features of this method are the easy availability of substrates, high yield, mild reaction conditions, tolerance of a variety of functional groups, and use of an environmentally friendly catalyst. A possible mechanism has also been proposed for the isomerization process.