Glucocorticoids suppress hypoxia‐induced <scp>COX</scp>‐2 and hypoxia inducible factor‐1α expression through the induction of glucocorticoid‐induced leucine zipper

Abstract

Dexamethasone-induced upregulation of GILZ not only inhibits the hypoxic-evoked induction of COX-2 expression and cell invasion but further blocks the HIF-1 pathway by destabilizing HIF-1α expression. Taken together, these findings suggest that the suppression of hypoxia-induced COX-2 by glucocorticoids is mediated by GILZ. Hence, GILZ is a potential key therapeutic target for suppression of inflammation under hypoxia.