Feasibility of 8‐<scp>OHdG</scp> formation and <scp>hOGG1</scp> induction in <scp>PBMCs</scp> for assessing oxidative <scp>DNA</scp> damage in the lung of <scp>COPD</scp> patients

Abstract

COPD patients manifest oxidative DNA damage of 8-OHdG along with impaired hOGG1 expression in the lung, whereas 8-OHdG formation and hOGG1 induction in PBMC could be a biomarker of oxidative DNA damage in the lung.