Molecular modelling, synthesis, cytotoxicity and anti‐tumour mechanisms of 2‐aryl‐6‐substituted quinazolinones as dual‐targeted anti‐cancer agents

Abstract

MJ65-70 are dual-targeted, tubulin- and JNK-binding, anti-cancer agents and induce cancer cell death through up-regulation of JNK and interfering in the dynamics of tubulin. Our work provides a new strategy and mechanism for developing dual-targeted anti-cancer drugs, contributing to clinical anti-cancer drug discovery and application.