Concepedia

Publication | Open Access

Promoter Methylation Precedes Chromosomal Alterations in Colorectal Cancer Development

DOIFull Paper Access

61

Citations

39

References

2006

Year

Sarah Derks, Cindy Postma, Peter T.M. Moerkerk, Sandra M. van den Bosch, Beatriz Carvalho, Mario Hermsen, Walter Giaretti, James G. Herman, Matty P. Weijenberg, Adriaan P. de Bruı̈ne,
Analytical Cellular Pathology

Abstract

Since promoter methylation was already present in nonprogressed adenomas without chromosomal alterations, we conclude that promoter methylation can be regarded as an early event preceding TP53 mutation and chromosomal abnormalities in colorectal cancer development.

References

YearCitations

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