Analysis of the Trajectory of Osteoarthritis Development in a Mouse Model by Serial Near‐Infrared Fluorescence Imaging of Matrix Metalloproteinase Activities

Abstract

Imaging of MMP activity in a mouse model of OA provides sensitive and consistent visualization of OA progression, beginning in the early stages of OA. In addition to facilitating the preclinical study of OA modulators, this approach has the potential for future translation to humans.