Iron‐Catalyzed Three‐Component Synthesis of α‐Amino Acid Derivatives

Abstract

Abstract An efficient, iron‐catalyzed, three‐component synthesis of arylglycines starting from readily available amides, glyoxalates, and arenes or heteroarenes has been developed. This method provides a versatile, atom‐economic, and cost‐effective route to arylglycines with water as the only byproduct. With carbamates as the amide component, various synthetically useful N ‐protected arylglycine derivatives could be prepared.