Journal of Biological Chemistry · 1973 · 411 citations · 35 references
Life SciencesBiochemistryEndocrinologyCell SignalingMetabolic RegulationSignal TransductionDiabetes MellitusHepatic PathophysiologyInsulin ResistanceInsulin Signaling In MetabolismReceptor PhysiologyRodent EndocrinologyHepatic Insulin ResistanceInsulin PhysiologyInsulin Receptor SignalingInsulin ReceptorsInsulin Resistance In HepatocytesInsulin Signal TransductionInsulin Signaling PathwayLiver Insulin Signaling
The interaction of insulin with its receptor was studied in purified liver plasma membranes and isolated hepatocytes of the obese hyperglycemic mouse (ob/ob) and its thin litter mate.The ob/ob mouse is a genetic mutant characterized by marked obesity, hyperinsulinism, and resistance to both endogenous and exogenous insulin.Under identical condi-
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