Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

Abstract

The interaction of insulin with its receptor was studied in purified liver plasma membranes and isolated hepatocytes of the obese hyperglycemic mouse (ob/ob) and its thin litter mate.The ob/ob mouse is a genetic mutant characterized by marked obesity, hyperinsulinism, and resistance to both endogenous and exogenous insulin.Under identical condi-