Experimental obstructive jaundice disrupts intestinal mucosal barrier by altering occludin expression: Beneficial effect of bombesin and neurotensin1

Abstract

Experimental obstructive jaundice induces regional loss of occludin expression in the intestinal epithelium, which may be a key factor contributing to the disruption of the mucosal barrier. Gut regulatory peptides BBS and NT prevent this alteration, leading to lower portal and systemic endotoxemia.