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Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

Tatyana Gurlo, Sergey Ryazantsev, Chang-jiang Huang, Michael W. Yeh, Howard A. Reber, O. Joe Hines, Timothy D. O’Brien, Charles Glabe, Peter C. Butler

American Journal Of Pathology · 2009 · 228 citations · 24 references

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References

24

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.3K citations

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Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4.1K citations

, , +17

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler, Juliette Janson, Susan Bonner‐Weir et al. · Diabetes · 2003 · 4K citations

, , +17

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

Christian Weyer, Clifton Bogardus, David M. Mott et al. · Journal of Clinical Investigation · 1999 · 2K citations · Full text

, , +11

Permeabilization of Lipid Bilayers Is a Common Conformation-dependent Activity of Soluble Amyloid Oligomers in Protein Misfolding Diseases

Rakez Kayed, Yuri Sokolov, Brian Edmonds et al. · Journal of Biological Chemistry · 2004 · 904 citations · Full text

, , +17