Melatonin and Bright‐Light Treatment for Rest–Activity Disruption in Institutionalized Patients with Alzheimer's Disease

Abstract

Light treatment alone did not improve nighttime sleep, daytime wake, or rest-activity rhythm. Light treatment plus melatonin increased daytime wake time and activity levels and strengthened the rest-activity rhythm. Future studies should resolve the question of whether these improvements can be attributed to melatonin or whether the two zeitgebers interact to amplify efficacy.