Pharmacokinetics and electrocardiographic pharmacodynamics of artemether‐lumefantrine (Riamet^®) with concomitant administration of ketoconazole in healthy subjects

Abstract

The concurrent administration of ketoconazole with co-artemether led to modest increases in artemether, DHA, and lumefantrine exposure in healthy subjects. Dose adjustment of co-artemether is probably unnecessary in falciparum malaria patients when administered in association with ketoconazole or other potent CYP3A4 inhibitors.