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ELECTROCARDIOGRAPHIC CHANGES DURING HEMODIALYSIS, WITH OBSERVATIONS ON CONTRIBUTION OF ELECTROLYTE DISTURBANCES TO DIGITALIS TOXICITY

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Article1 July 1953ELECTROCARDIOGRAPHIC CHANGES DURING HEMODIALYSIS, WITH OBSERVATIONS ON CONTRIBUTION OF ELECTROLYTE DISTURBANCES TO DIGITALIS TOXICITYROBERT M. KOHN, M.D., JOHN E. KILEY, M.D.ROBERT M. KOHN, M.D., JOHN E. KILEY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-1-38 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExtracorporeal hemodialysis is often lifesaving in the treatment of acute renal insufficiency, but the procedure itself is not without danger. Heparinization may be accompanied by hemorrhage; the patient may accidentally undergo in a short period of time a net gain or loss of blood volume from or into the machine1; elevation of blood pressure may occur,2and cardiac arrhythmias may be produced. In the course of observations on these cardiovascular changes during 13 consecutive hemodialyses with a Kolff type dialyzer at the Albany Hospital, electrocardiographic changes were noted in 11 instances and arrhythmias in three. It was felt that such...Bibliography1. WolfRempKileyCurrie AVDGJEGD: Artificial kidney function: kinetics of hemodialysis, J. Clin. Investigation 30: 1062, 1951. CrossrefMedlineGoogle Scholar2. MerrillGoodaleSwan JPWTRC: Observations on the pressor response occurring during dialysis with the artificial kidney (abst.), J. Clin. Investigation 30: 660, 1951. Google Scholar3. Wolf AV: The artificial kidney, Science 115: 193, 1952. CrossrefMedlineGoogle Scholar4. LarsonGreenberg CEDM: The analysis of calcium in blood and other biological material by titration with ceric sulfate, J. Biol. Chem. 123: 199, 1938. CrossrefGoogle Scholar5. MerrillLevineSomervilleSmith JPHDWS: Clinical recognition and treatment of acute potassium intoxication, Ann. Int. Med. 33: 797, 1950. LinkGoogle Scholar6. LownSalzbergEnselbergWeston BHCDRE: Interrelation between potassium metabolism and digitalis toxicity in heart failure, Proc. Soc. Exper. Biol. and Med. 76: 797, 1951. CrossrefMedlineGoogle Scholar7. LownWellerWyattHoigneMerrill BJMNRJP: Effects of alterations of body potassium on digitalis toxicity (abst.), J. Clin. Investigation 31: 648, 1952. Google Scholar8. LevineVazifdarLownMerrill HDJPBJP: "Tent-shaped" T waves of normal amplitude in potassium intoxication, Am. Heart J. 43: 437, 1952. CrossrefMedlineGoogle Scholar9. Merrill AJ: The significance of the electrocardiogram in electrolyte disturbances, Am. Heart J. 43: 634, 1952. CrossrefMedlineGoogle Scholar10. Sharpey-Schafer EP: Potassium effects on T wave inversion in myocardial infarction and preponderance of a ventricle, Brit. Heart J. 5: 80, 1943. CrossrefMedlineGoogle Scholar11. ErnsteneProudfit ACWF: Differentiation of QT interval changes in hypocalcemia and hypopotassemia, Am. Heart J. 38: 260, 1949. CrossrefMedlineGoogle Scholar12. Baker JB: The influence of calcium and potassium ions on the toxicity of ouabain, Brit. J. Pharmacol. 2: 259, 1947. CrossrefGoogle Scholar13. BowerMengle JOHA: The additive effect of calcium and digitalis, J. A. M. A. 106: 1151, 1936. CrossrefGoogle Scholar14. Cohen BM: Digitalis poisoning and its treatment, New England J. Med. 246: 225, 1952. CrossrefMedlineGoogle Scholar15. GoldenBrams JSWA: Mechanism of the toxic effects from combined use of calcium and digitalis, Ann. Int. Med. 11: 1084, 1938. LinkGoogle Scholar16. Lieberman AL: Studies on calcium. VI. Some interrelationships of the cardiac activities of calcium gluconate and Scillaren-B, J. Pharmacol. and Exper. Therap. 47: 183, 1933. Google Scholar17. SampsonAlbertsonKondo JJECB: Effect on man of potassium administration in relation to digitalis glycosides with special reference to blood serum potassium, the electrocardiogram, and ectopic beats, Am. Heart J. 26: 164, 1943. CrossrefGoogle Scholar18. Cohen BM: Digitalis poisoning and its treatment (concluded), New England J. Med. 246: 254, 1952. CrossrefMedlineGoogle Scholar19. EnselbergSimmonsMintz CDHGAA: The effect of potassium upon the heart with special reference to the possibility of treatment of toxic arrhythmias due to digitalis, Am. Heart J. 39: 713, 1950. CrossrefMedlineGoogle Scholar20. CattellGoodell MH: On mechanism of digitalis glycosides on muscle, Science 86: 106, 1937. CrossrefMedlineGoogle Scholar21. BoyerPoindexter PKCA: The influence of digitalis on the electrolyte and water balance of heart muscle, Am. Heart J. 20: 586, 1940. CrossrefGoogle Scholar22. CalhounHarrison JATR: The effect of digitalis on the potassium content of cardiac muscle of dogs, J. Clin. Investigation 9: 393, 1931. CrossrefGoogle Scholar23. Hagen P: The effects of digilanid C in varying dosage upon potassium and water content of rabbit heart muscle, J. Pharmacol. and Exper. Therap. 67: 50, 1939. Google Scholar24. Wedd AM: The influence of Digoxin on the potassium content of the heart, J. Pharmacol. and Exper. Therap. 65: 268, 1939. Google Scholar25. Wollenberger A: The energy metabolism of the failing heart and the metabolic action of the cardiac glycosides, J. Pharmacol. and Exper. Therap. 97 part 2: 311, 1949. Google Scholar26. WoodMoe EHGK: Blood electrolyte changes in the heart-lung preparation with special reference to the effects of cardiac glycosides, Am. J. Physiol. 137: 6, 1942. CrossrefGoogle Scholar27. WoodMoe EHGK: Electrolyte and water content of the ventricular muscle of the heart-lung preparation with special reference to the effects of cardiac glycosides, Am. J. Physiol. 136: 515, 1942. CrossrefGoogle Scholar28. ZwemerLowenstein RLBE: Cortin-like effects of steroid glycosides on potassium, Science 91: 75, 1940. CrossrefMedlineGoogle Scholar29. SalterSciariniGenmel WTLJJ: Inotropic synergism of cardiac glucosides with calcium acting on the frog's heart in artificial media, J. Pharmacol. and Exper. Therap. 96: 372, 1949. MedlineGoogle Scholar30. SmithWinklerHoff PKAWHE: Calcium and digitalis synergism, Arch. Int. Med. 64: 322, 1939. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 3, 1953.From the Department of Medicine, Albany Medical College and Albany Hospital, Albany, N. Y.This work was done while Dr. Kiley was Research Fellow in Medicine of the American College of Physicians, 1951-52, and Dr. Kohn was a Fellow of the National Heart Institute. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffect of hemodialysis on the signal-averaged electrocardiogramCardiac Arrhythmias in End-Stage Renal Disease: Prevalence, Risk Factors, and ManagementDialysisMechanism and prevention of cardiac arrhythmias in chronic hemodialysis patientsPeritonealspülung, künstliche Niere und andere therapeutische Methoden bei akuter und chronischer Niereninsuffizienz bzw. akuten schweren Vergiftungen etc.Peritoneal Dialysis and Hemodialysis of Tritiated DigoxinGEORGE L. ACKERMAN, M.D., F.A.C.P., JAMES E. DOHERTY, M.D., F.A.C.P., WILLIAM J. FLANIGAN, M.D.A Comparison of Digitalis Intoxication in Two Separate PeriodsMORTON H. DUBNOW, M.D., HOWARD B. BURCHELL, M.D., PH.D.The possible role of sex in digitalis toleranceTrial by digitalisEffect of digitalis on conduction of the heartSelected electrocardiographic changes during acute renal failure and hemodialysisThe mechanism of arrhythmias during insulin-induced hypoglycemiaElectrolyte and electrocardiographic changes in the course of hemodialysisThe toxicology of digitalis∗Arrhythmias and conduction disturbances due to digitalisTreatment of Acute Massive Digitalis Poisoning by Administration of a Chelating AgentMetabolic alterations during hemodialysis with the disposable coil artificial kidneyElectrocardiographic Changes during Hemodialysis with the Artificial KidneyElectrocardiographic Changes during Hemodialysis with the Artificial KidneyÜber die extrarenale Reinigung des Organismus von retinierten Harnfixa bei NiereninsuffizienzDie apparative Blut-Dialyse (?K�nstliche Niere?) �berblick und eigene ErfahrungenThe Clinical Use of Digitalis PreparationsDialysis in the Treatment of Uremia: Artificial KidneyTreatment of hypertensive disease with hydralazineCurrent Concepts in Digitalis Therapy 1 July 1953Volume 39, Issue 1Page: 38-50KeywordsAcute renal failureArrhythmiaBlood pressureBlood volumeElectrocardiographyHeartHemorrhageHospital medicineToxicity ePublished: 1 December 2008 Issue Published: 1 July 1953 PDF downloadLoading ...

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