The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations

Life Sciences, Biotechnology, Molecular Biology +12

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

R. Palmer Beasley, Chia‐Chin Lin, Lu‐Yu Hwang et al. · The Lancet · 1981 · 2.9K citations

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A short amino acid sequence able to specify nuclear location

Daniel Kalderon, Bruce Roberts, William D. Richardson et al. · Cell · 1984 · 2.6K citations

Life Sciences, Genetics, Molecular Biology +9

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

Chang‐Min Kim, K. Koike, Izumu Saito et al. · Nature · 1991 · 1.2K citations

Medicine, Molecular Biology, Oncology +13

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

Francis V. Chisari, Kathleen Klopchin, Takashi Moriyama et al. · Cell · 1989 · 701 citations · Full text

Medicine, Molecular Biology, Oncology +14