Zoledronic acid induces formation of a pro‐apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts <i>in vivo</i> and in MCF‐7 cells <i>in vitro</i>

Abstract

This study provided the first conclusive evidence that pro-apoptotic ApppI is a biologically significant molecule, and demonstrated that IPP/ApppI analysis is a sensitive tool for investigating pathways involved in BP action.