Prognostic impact of <i>TP53</i> mutation status for adult patients with supratentorial World Health Organization Grade II astrocytoma or oligoastrocytoma

Abstract

TP53 mutations are common early events in the pathogenesis of WHO Grade II astrocytoma or oligoastrocytoma. In the current study, positive TP53 mutation status (but not P53 overexpression/accumulation) was found to be an independent unfavorable predictor of survival, progression-free survival, and time to malignant transformation. The therapeutic implications of these findings have yet to be determined.