Mechanisms of inhibition of human benign prostatic hyperplasia <i>in vitro</i> by the luteinizing hormone‐releasing hormone antagonist cetrorelix

Abstract

The results show that in vitro cetrorelix can directly inhibit the proliferation rate of the human BPH-1 cell line by counteracting growth factors like IGF-I and -II and FGF-2, and downregulating the LHRH receptor and α-adrenergic receptors, as well as transcription factors.