Concepedia

Mechanisms mediating the ability of caffeine to influence MDMA (‘Ecstasy’)‐induced hyperthermia in rats

Natacha Vanattou‐Saïfoudine, Ruth McNamara, Andrew Harkin

British Journal of Pharmacology · 2010 · 39 citations · 53 references

DOIFull text

Open access

Abstract

A mechanism comprising 5-HT and catecholamines is proposed to mediate MDMA-induced hyperthermia. A combination of adenosine A(2A) receptor antagonism and PDE inhibition can account for the exacerbation of MDMA-induced hyperthermia by caffeine.

References

53

Guide to Receptors and Channels (GRAC), 5th edition

S P H Alexander, Alistair Mathie, JA Peters · British Journal of Pharmacology · 2011 · 1.9K citations · Full text

Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

J.A. Henry, K.J. Jeffreys, S. Dawling · The Lancet · 1992 · 734 citations

, , +8

A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5‐HT<sub>1</sub> and 5‐HT<sub>2</sub> receptors

Guy M. Goodwin, A. Richard Green · British Journal of Pharmacology · 1985 · 380 citations · Full text

, , +20

Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens

Marcello Solinas, Sergi Ferré, Zhi‐Bing You et al. · Journal of Neuroscience · 2002 · 335 citations · Full text

The pharmacology of the acute hyperthermic response that follows administration of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) to rats

Annis O. Mechan, B. Moreno Esteban, Esther O’Shea et al. · British Journal of Pharmacology · 2002 · 219 citations · Full text