THE DISTURBANCE OF THE NORMAL BACTERIAL ECOLOGY BY THE ADMINISTRATION OF ANTIBIOTICS WITH THE DEVELOPMENT OF NEW CLINICAL SYNDROMES

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Article1 December 1952THE DISTURBANCE OF THE NORMAL BACTERIAL ECOLOGY BY THE ADMINISTRATION OF ANTIBIOTICS WITH THE DEVELOPMENT OF NEW CLINICAL SYNDROMESDAVID T. SMITH, M.D., F.A.C.P.DAVID T. SMITH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-6-1135 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvidence is accumulating to show that the complex balance which exists among microörganisms constituting the normal flora of the body is disturbed by the prolonged administration of the newer antibiotics. This may result in the development of secondary vitamin deficiencies or the evolution of new infectious disease syndromes.The importance of the normal microbiologic flora in man was not appreciated until it was disorganized by the administration of the newer antibiotics. The basic phenomenon is not new, and biologists dealing with parasitic diseases of plants are familiar with the importance of the normal flora of the soil and its influence...Bibliography1. Waksman SA: Antagonistic relations of microörganisms, Bact. Rev. 5: 231 (Sept.) 1941. CrossrefMedlineGoogle Scholar2. WolfWolf FAFT: The fungi, vol. 2, 1947, John Wiley and Sons, New York, p. 279. Google Scholar3. Garrett SD: Ecology of the root inhabiting fungi, Biol. Reviews 25: 220 (April) 1950. CrossrefMedlineGoogle Scholar4. Davison WC: The duodenal content of infants in health, and during and following diarrhea, Am. J. Dis. Child. 29: 743 (June) 1925. CrossrefGoogle Scholar5. MillerHammondTompkins CPCWM: The incidence of bacteremia in mice subject to total body x-radiation, Science 111: 540 (May 19) 1950. CrossrefMedlineGoogle Scholar6. Smith DT: Bacterial ecology and flora of the normal body, in Zinsser's Textbook of bacteriology, 1942, Appleton-Century-Crofts, New York. Google Scholar7. 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HAVILAND, M.D., F.A.C.P. 1 December 1952Volume 37, Issue 6 Page: 1135-1143 Keywords Antibiotics Bacteriology Biologists Ecology Infectious diseases Parasitic diseases ePublished: 1 December 2008 Issue Published: 1 December 1952 PDF downloadLoading ...